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Other chemicals quarry transcriptional factors as the crow flies, in which case toxicant binding alters interactions with adscititious proteins and coactivators which unsettle binding of the transcription complex to promoters or other gene regulatory ele- ments.
Protected activation during pregnancy in rats leads to a postpubertal surfacing of disrupted latent barrier, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a creative neurodevelopmental paragon of schizophrenia. Pharmaceutical manufacturers lack patients with altogether specific indications to participate in clinical trials.
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